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KMID : 0370220040480050261
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Yakhak Hoeji
2004 Volume.48 No. 5 p.261 ~ p.265
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Immunoactivities of PVMP a Protein-polysaccharide Fraction Isolated from Mycelial Culture of Psathyrella veluyina
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Hyeong-Soo Chung
Ji-Seon Lee
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Abstract
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ln the previous report, we described the marked antitumor and immunomodulatory activities of PVP, a protein-polysaccharide fraction of a Korean wild mushroom Psathyrella ve luyina. In this study, a protein-polysaccharide fraction, PVMP was prepared from the shake-cultured mycelia of the same mushroom and its immunoactivities as well as chemical compositions were investigated. At 200μg/ml, PVMP weakly stimulated the BALB/c mouse splenic Iymphocytes to form Iymphoblasts and upregulated the expression of CD25 molecules, but failed to stimulate peritoneal macrophages. In chemical analysis these two protein-polysaccharide fractions were found to be quite different in that the carbohydrate contents of PVMP and PVP, respectively was 85.3% and 4l.2%. These results reveals that PVMP, unlike PVP, is a moderate immunostimulator on the immune system.
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KEYWORD
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